About the Mears LabOur lab is eager to resolve long-standing questions about the key factors that alter mitochondrial structure and physiology, leading to organelle dysfunction in human pathologies. To this end, we investigate proteins that regulate mitochondrial dynamics to provide mechanistic insight into the regulation of the mitochondrial fission complex and the functional roles of proteins that drive this process.
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News and EventsApril 2024: Preprint of Drp1 Lattice availableExcellent collaboration with Stagg Lab looks are novel features of the Drp1 lattice interacting with lipid nanotubes in vitro. BioRxiv link April 2024: Congratulations Dayanlee!Dayanlee de León Cordero joined the Mears lab as a PREP Scholar last summer after completing her BS in Computer Science at U Puerto Rico - Rio Piedras. She accepted an offer to join the BSTP program at CWRU for the coming year! So we have the pleasure of seeing her in Cleveland for the next few years. January 2024: New papers out in Nat CommunsKristy's structural studies of Drp1 in it native state are published! Nat Communs link She also contributed to this excellent paper in collaboration with the Ramachandran lab. Nat Communs link May 2023: Diekhoff AwardHonored to receive the Diekhoff Awardfor graduate mentoring. This is special since the selection is made by students. Grateful to have lab members that promote the inclusive and welcoming environment that made this possible. Feb 2023: Brianna's Paper out in HMGThrilled to share that Brianna's paper characterizing EMPF1 patient mutations in Drp1 is out. Click here! |