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Research

In the Mears Lab, we use combinatorial approaches, including cryo-electron microscopy, biochemical and cellular methods, and cancer stem cell models, to address fundamental questions in cell biology and human disease. We are fortunate to have regular interactions within the Department of Pharmacology, the Center for Mitochondrial Research and Therapeutics, the Cleveland Center for Membrane and Structural Biology (CCMSB), and the Case Comprehensive Cancer Center (CCCC). These communities support our research interests and foster the development of innovative scientists.   
 
Current Interests in the Mears Lab include: 

1. Structure and function of proteins that drive mitochondrial fission
   Using a combination of biochemical and structural methods, we are working to define the fundamental properties of proteins that coordinate mitochondrial membrane division
2. Interactions that regulate and govern mitochondrial dynamics
   Interactions with various biomolecules, including proteins and lipids, govern mitochondrial dynamics. We are working to define these interactions and reconstitute these factors into our in vitro assays.
3. How mitochondrial fission is altered in human diseases, including neurodegeneration and cancer
   Mitochondrial dynamics can be altered in several human diseases due to mutations and/or cellular reprogramming. Our goal is to identify specific deficiencies and identify novel therapeutic targets.
4. Correlate changes in mitochondrial structure with organelle function
   Changes in mitochondrial dynamics coincide with functional changes in cellular metabolism. We study altered metabolic programing and mitochondrial morphology in cancer stem cells to better define the relationship between bioenergetics and cell signaling. 

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